蔣日成,男,1976年8月生,腫瘤學(xué)博士、博士后,天津醫(yī)科大學(xué)附屬腫瘤醫(yī)院、天津市肺癌診療中心、肺部腫瘤內(nèi)科主任醫(yī)師、副教授、碩士生導(dǎo)師,主要從事肺癌的早期診斷、綜合治療、靶向治療和個(gè)體化治療以及免疫治療。從博士期間即致力于腫瘤發(fā)生、發(fā)展機(jī)制研究,并力爭(zhēng)基礎(chǔ)研究與臨床實(shí)踐相結(jié)合,密切追蹤國(guó)際最前沿肺癌化療、靶向治療進(jìn)展,切實(shí)提高自身肺癌診斷、治療水平。主要研究方向是肺癌發(fā)生和耐藥的機(jī)制研究。曾于2005年赴法國(guó)進(jìn)行癌基因與腫瘤發(fā)生機(jī)制研究;于2007-2009年在美國(guó)哥倫比亞大學(xué)、馬里蘭大學(xué)進(jìn)行腫瘤干細(xì)胞和人類(lèi)胚胎干細(xì)胞的研究。積極探索科研成果向臨床一線轉(zhuǎn)化的途徑。并且在美國(guó)進(jìn)行博士后研究期間,作為獨(dú)立申請(qǐng)人成功獲得美國(guó)國(guó)防部博士后研究項(xiàng)目基金:PC080759-“Post-translational Modification of Androgen Receptor in Prostate Cancer” (編號(hào)GRANT00475671)。于2009年2月回國(guó)至天津醫(yī)科大學(xué)附屬腫瘤醫(yī)院工作?,F(xiàn)為國(guó)家自然科學(xué)基金81000899、天津市科委重點(diǎn)項(xiàng)目11JCZDJC18900負(fù)責(zé)人。近年發(fā)表論著:1)Jiang R, Jin Z, Liu Z, Sun L, Wang L, Li K. Correlation of activated STAT3 expression with clinicopathologic features in lung adenocarcinoma and squamous cell carcinoma. Mol Diagn Ther. 2011 Dec 1;15(6):347-52. 2)Jiang R, Xue S, Jin Z. Stable knockdown of MYCN by lentivirus-based RNAi inhibits human neuroblastoma cells growth in vitro and in vivo. Biochem Biophys Res Commun. 2011 Jul 1;410(2):364-70. 3)Jiang R, Cabras G, Sheng W, Zeng Y, Ooka T. Synergism of BARF1 with Ras induces malignant transformation in primary primate epithelial cells and human nasopharyngeal epithelial cells. Neoplasia. 2009; 11(9):964-73. 4)Jiang RC, Qin HD, Zeng MS, Huang W, Feng BJ, Zhang F, Chen HK, Jia WH, Chen LZ, Feng QS, Zhang RH, Yu XJ, Zheng MZ, Zeng YX. A functional variant in the transcriptional regulatory region of gene LOC344967 cosegregates with disease phenotype in familial nasopharyngeal carcinoma. Cancer Res. 2006; 66(2):693-700. 5)Xu K, Shimelis H, Linn DE, Jiang R, Yang X, Sun F, Guo Z, Chen H, Li W, Chen H, Kong X, Melamed J, Fang S, Xiao Z, Veenstra TD, Qiu Y. Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination. Cancer Cell. 2009; 15(4):270-82. 6)Zhao X, Heng JI, Guardavaccaro D, Jiang R, Pagano M, Guillemot F, Iavarone A, Lasorella A. The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein. Nat Cell Biol. 2008; 10(6):643-53. 7)蔣日成,李凱。以分子分型為基礎(chǔ)的肺癌靶向治療...
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